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pbrm1  (Bethyl)


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    Bethyl pbrm1
    Evaluation of SWI/SNF components and TAZ expression in human ITPN samples. ( A ) Expression of SWI/SNF components, including BRG1, BRM, ARID1A, and <t>PBRM1,</t> in human ITPN specimens. Additionally, the expression levels of pAKT and TAZ were analyzed. Black, blue, green, and red indicate negative, weak, moderate, and strong expression, respectively. Cases with reduced expression of any SWI/SNF complex component are shown in yellow . ( B ) Summary of BRG1 staining for human IPMN and ITPN samples. Immunohistochemistry for BRG1 in IPMN (n = 20), ITPN (n = 12), and adjacent normal pancreas (n = 3) specimens. Images of the adjacent normal pancreas were captured from the same tissue slide as IPMN or ITPN, if available. Scale bar, 20 mm. Tables on the right show the number of samples classified as ITPN or IPMN and their staining intensity. Statistical analysis was performed using the Mann–Whitney U test. ( C ) Analysis of Spearman’s correlation coefficients and scatterplots with jitter and linear regression. There was a significant negative correlation between BRG1 and TAZ expression (−0.803). There was a moderate negative correlation between ARID1A or BRM and TAZ expression (−0.422 and −0.518, respectively). No correlation was observed between PBRM1 or pAKT and TAZ expression (0.147 and 0.125, respectively). ( D ) Representative cases are shown. Scale bar, 20 μm.
    Pbrm1, supplied by Bethyl, used in various techniques. Bioz Stars score: 94/100, based on 118 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/a301+591a/PBRM1+Antibody/pmc12634868-17-0-2
    Average 94 stars, based on 118 article reviews
    pbrm1 - by Bioz Stars, 2026-09
    94/100 stars

    Images

    1) Product Images from "Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway"

    Article Title: Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

    Journal: Cellular and Molecular Gastroenterology and Hepatology

    doi: 10.1016/j.jcmgh.2025.101639

    Evaluation of SWI/SNF components and TAZ expression in human ITPN samples. ( A ) Expression of SWI/SNF components, including BRG1, BRM, ARID1A, and PBRM1, in human ITPN specimens. Additionally, the expression levels of pAKT and TAZ were analyzed. Black, blue, green, and red indicate negative, weak, moderate, and strong expression, respectively. Cases with reduced expression of any SWI/SNF complex component are shown in yellow . ( B ) Summary of BRG1 staining for human IPMN and ITPN samples. Immunohistochemistry for BRG1 in IPMN (n = 20), ITPN (n = 12), and adjacent normal pancreas (n = 3) specimens. Images of the adjacent normal pancreas were captured from the same tissue slide as IPMN or ITPN, if available. Scale bar, 20 mm. Tables on the right show the number of samples classified as ITPN or IPMN and their staining intensity. Statistical analysis was performed using the Mann–Whitney U test. ( C ) Analysis of Spearman’s correlation coefficients and scatterplots with jitter and linear regression. There was a significant negative correlation between BRG1 and TAZ expression (−0.803). There was a moderate negative correlation between ARID1A or BRM and TAZ expression (−0.422 and −0.518, respectively). No correlation was observed between PBRM1 or pAKT and TAZ expression (0.147 and 0.125, respectively). ( D ) Representative cases are shown. Scale bar, 20 μm.
    Figure Legend Snippet: Evaluation of SWI/SNF components and TAZ expression in human ITPN samples. ( A ) Expression of SWI/SNF components, including BRG1, BRM, ARID1A, and PBRM1, in human ITPN specimens. Additionally, the expression levels of pAKT and TAZ were analyzed. Black, blue, green, and red indicate negative, weak, moderate, and strong expression, respectively. Cases with reduced expression of any SWI/SNF complex component are shown in yellow . ( B ) Summary of BRG1 staining for human IPMN and ITPN samples. Immunohistochemistry for BRG1 in IPMN (n = 20), ITPN (n = 12), and adjacent normal pancreas (n = 3) specimens. Images of the adjacent normal pancreas were captured from the same tissue slide as IPMN or ITPN, if available. Scale bar, 20 mm. Tables on the right show the number of samples classified as ITPN or IPMN and their staining intensity. Statistical analysis was performed using the Mann–Whitney U test. ( C ) Analysis of Spearman’s correlation coefficients and scatterplots with jitter and linear regression. There was a significant negative correlation between BRG1 and TAZ expression (−0.803). There was a moderate negative correlation between ARID1A or BRM and TAZ expression (−0.422 and −0.518, respectively). No correlation was observed between PBRM1 or pAKT and TAZ expression (0.147 and 0.125, respectively). ( D ) Representative cases are shown. Scale bar, 20 μm.

    Techniques Used: Expressing, Staining, Immunohistochemistry, MANN-WHITNEY

    Related Articles

    other:

    Article Title: β-catenin functions as a molecular adapter for disordered cBAF interactions.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies SMARCA4 (IP, WB) Santa Cruz Biotechnology Cat# sc-374197; RRID:AB_10990135 SMARCA4 (ChIP, WB) Proteintech Cat# 21634-1-AP; RRID:AB_10858784 SMARCA4 (IHC) Abcam Cat# ab108318; RRID:AB_10889900 SMARCA2 (WB) Abcam Cat# ab15597; RRID:AB_443214 β-catenin (ChIP, WB) Invitrogen Cat# 71-2700; RRID:AB_88035 β-catenin (IHC) Cell Signaling Technology Cat# 8480; RRID:AB_11127855 SF-1 (ChIP, IP) R&D Systems Cat# PPN16650C SF-1 (WB) Millipore Cat# 07-618; RRID:AB_310756 SF-1 (IHC) Thermo Fisher Cat# 2516-MSM7-P1 IgG (IP) Santa Cruz Biotechnology Cat# sc-2025; RRID:AB_737182 FLAG (co-IP, WB) Millipore Cat# F1804; RRID:AB_262044 ARID1A (ChIP, WB) Cell Signaling Technology Cat# 12354S; RRID:AB_2637010 ARID1A (IP) Santa Cruz Biotechnology Cat# sc-32761; RRID:AB_673396 ARID1B (WB) Santa Cruz Biotechnology Cat# sc-32762; RRID:AB_2060367 DPF1 (WB) Proteintech Cat# 21769-1-AP; RRID:AB_3085672 DPF2 (WB) Proteintech Cat# 12111-1-AP; RRID:AB_2095574 DPF3 (WB) Proteintech Cat# 68646-1-Ig; RRID:AB_3670389 PBRM1 (ChIP, WB) Bethyl Laboratories Cat# A301-591A; RRID:AB_1078808 BRD9 (ChIP, WB) Abcam Cat# ab137245 H3K4me1 (ChIP) Abcam Cat# ab8895; RRID:AB_306847 H3K4me3 (ChIP) Millipore Cat# 05-745R; RRID:AB_1587134 H3K27ac (ChIP) Abcam Cat# ab4729; RRID:AB_2118291 H3K27me3 (ChIP) Active Motif Cat# 39155; RRID:AB_2561020 CTCF (ChIP) Millipore Cat# 07-729; RRID:AB_441965 FOXO3 (WB) Cell Signaling Technology Cat# 12829; RRID:AB_2636990 SOX2 (WB) Millipore Cat# AB5603; RRID:AB_2286686 YAP1 (WB) Proteintech Cat# 13584-1-AP; RRID:AB_2218915 CBP/p300 (WB) Proteintech Cat# 22277-1-AP; RRID:AB_3085692 CBP/p300 (ChIP) Abcam Cat# ab14984; RRID:AB_301550 c-Jun (WB) Cell Signaling Technology Cat# 9165; RRID:AB_2130165 Vinculin (WB) Sigma-Aldrich Cat# V9131; RRID:AB_477629 β-actin (WB) GeneTex Cat# GTX629630; RRID:AB_2728646 HRP conjugated mouse anti-rabbit Santa Cruz Biotechnology Cat# sc-2357; RRID:AB_628497 HRP conjugated anti-mouse Santa Cruz Biotechnology Cat# sc-516102; RRID:AB_2687626 Chemicals, peptides, and recombinant proteins BRM014 This paper N/A FHD-286 MedChemExpress Cat# HY-144835 AU-15330 MedChemExpress Cat# HY-145388 cOmplete ULTRA Roche Cat# 5892791001 NuPAGE 4-12% bis tris polyacrylamide gel Thermo Fisher Cat# NP0323BOX NuPAGE 3-8% Tris-Acetate Protein Gels Thermo Fisher Cat# EA03785BOX MOPS SDS running buffer Thermo Fisher Cat# NP0001 Novex NuPAGE Tris-Acetate SDS running buffer Thermo Fisher Cat# LA0041 (Continued on next page) Molecular Cell 85, 3041–3056.e1–e9, August 21, 2025 e1

    Article Title: Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies.
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    Article Title: Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies SMARCA2/BRM Bethyl Laboratories Cat#A301-016A; RRID: AB_2193933 SMARCA4/BRG1 Cell Signaling Technology Cat# 52251S; RRID: AB_2799410 PBRM1 Bethyl Laboratories Cat# A301-591A; RRID: AB_1078808 Vinculin Cell Signaling Technology Cat# 18799S; RRID: AB_2714181 c-Myc Abcam Cat# ab32072; RRID: AB_731658 Cleaved PARP (Asp214) Cell Signaling Technology Cat# 9541; RRID: AB_331426 POU2F3 Cell Signaling Technology Cat# 92579 ASCL1 Abcam Cat# ab74065; RRID: AB_1859937 POU2AF2 Cell Signaling Technology Cat# 20217s N-Myc Santa Cruz Cat# sc-53993; RRID: AB_831602 GFI1B Santa Cruz Cat#sc-28356; RRID: AB_2110132 NEUROD1 Abcam Cat#ab60704; RRID: AB_943491 HA-tag Cell Signaling Technology Cat# 3724s; RRID: AB_1549585 SMARCD1 Santa Cruz Cat#sc-135843; RRID: AB_2192137 POU2AF1 Cell Signaling Technology Cat#43079s IRF4 Cell Signaling Technology Cat# 4964s; RRID: AB_10698467 ARID1A Santa Cruz Cat# sc-373784; RRID: AB_10917727 DCLK1 Abcam Cat# ab109029; RRID: AB_10864128 BRG1 Abcam Cat# ab108318; RRID: AB_10889900 POU2F3 Cell Signaling Technology Cat# mAB#36135/clone E5N2D; RRID: AB_2924784 CD38 Ventana Cat# 760-4785/clone SP149 POU2AF1 Thermo Fisher Scientific Cat# PA5-121026; RRID: AB_2914598 (Continued on next page) e1 Cancer Cell 42, 1336–1351.e1–e9, August 12, 2024

    Western Blot:

    Article Title: Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells
    Article Snippet: Antibody , anti-BAF250A (Rabbit monoclonal) , Cell Signaling Technology , Cat# 12,354 , WB (1:1000). .. Antibody , anti-PBAF/PBRM (Rabbit polyclonal) , Bethyl , Cat# A301-591A , WB (1:1000). .. Antibody , anti- α-Tubulin (Mouse monoclonal) , Sigma Aldrich , Cat# T5169 , WB (1:3000).

    Virus:

    Article Title: The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
    Article Snippet: In brief By developing a 3D spheroid system for hPSC-hepatocytes differentiation and combining it with genomic approaches, Jaenisch and colleagues identified a role for THRB in regulating hPSC-hepatocytes maturation through chromatinremodeling complex pBAF.. The differentiated hPSC-hepatocytes engraft into non-damaged mouse liver and proliferate in vitro in response to liver regeneration signals.

    Recombinant:

    Article Title: The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
    Article Snippet: In brief By developing a 3D spheroid system for hPSC-hepatocytes differentiation and combining it with genomic approaches, Jaenisch and colleagues identified a role for THRB in regulating hPSC-hepatocytes maturation through chromatinremodeling complex pBAF.. The differentiated hPSC-hepatocytes engraft into non-damaged mouse liver and proliferate in vitro in response to liver regeneration signals.

    Knock-Out:

    Article Title: The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes.
    Article Snippet: In brief By developing a 3D spheroid system for hPSC-hepatocytes differentiation and combining it with genomic approaches, Jaenisch and colleagues identified a role for THRB in regulating hPSC-hepatocytes maturation through chromatinremodeling complex pBAF.. The differentiated hPSC-hepatocytes engraft into non-damaged mouse liver and proliferate in vitro in response to liver regeneration signals.

    Immunohistochemistry:

    Article Title: SMARCB1 Loss in Poorly Differentiated Chordomas Drives Tumor Progression.
    Article Snippet: From the Lineberger Comprehensive Cancer Center,* Curriculum in Toxicology and Environmental Medicine,y and the Department of Pathology and Laboratory Medicine,yy University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina; the Departments of Pathology and Laboratory Medicinez and Microbiology & Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada; the Department of Molecular Oncology,x British Columbia Cancer Research Institute, Vancouver, British Columbia, Canada; the Department of Otolaryngology and Neurosurgery,{ University of Michigan, Ann Arbor, Michigan; and Canada’s Michael Smith Genome Sciences Centre at BC Cancer,** Vancouver, British Columbia, Canada



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    Evaluation of SWI/SNF components and TAZ expression in human ITPN samples. ( A ) Expression of SWI/SNF components, including BRG1, BRM, ARID1A, and <t>PBRM1,</t> in human ITPN specimens. Additionally, the expression levels of pAKT and TAZ were analyzed. Black, blue, green, and red indicate negative, weak, moderate, and strong expression, respectively. Cases with reduced expression of any SWI/SNF complex component are shown in yellow . ( B ) Summary of BRG1 staining for human IPMN and ITPN samples. Immunohistochemistry for BRG1 in IPMN (n = 20), ITPN (n = 12), and adjacent normal pancreas (n = 3) specimens. Images of the adjacent normal pancreas were captured from the same tissue slide as IPMN or ITPN, if available. Scale bar, 20 mm. Tables on the right show the number of samples classified as ITPN or IPMN and their staining intensity. Statistical analysis was performed using the Mann–Whitney U test. ( C ) Analysis of Spearman’s correlation coefficients and scatterplots with jitter and linear regression. There was a significant negative correlation between BRG1 and TAZ expression (−0.803). There was a moderate negative correlation between ARID1A or BRM and TAZ expression (−0.422 and −0.518, respectively). No correlation was observed between PBRM1 or pAKT and TAZ expression (0.147 and 0.125, respectively). ( D ) Representative cases are shown. Scale bar, 20 μm.
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    Evaluation of SWI/SNF components and TAZ expression in human ITPN samples. ( A ) Expression of SWI/SNF components, including BRG1, BRM, ARID1A, and <t>PBRM1,</t> in human ITPN specimens. Additionally, the expression levels of pAKT and TAZ were analyzed. Black, blue, green, and red indicate negative, weak, moderate, and strong expression, respectively. Cases with reduced expression of any SWI/SNF complex component are shown in yellow . ( B ) Summary of BRG1 staining for human IPMN and ITPN samples. Immunohistochemistry for BRG1 in IPMN (n = 20), ITPN (n = 12), and adjacent normal pancreas (n = 3) specimens. Images of the adjacent normal pancreas were captured from the same tissue slide as IPMN or ITPN, if available. Scale bar, 20 mm. Tables on the right show the number of samples classified as ITPN or IPMN and their staining intensity. Statistical analysis was performed using the Mann–Whitney U test. ( C ) Analysis of Spearman’s correlation coefficients and scatterplots with jitter and linear regression. There was a significant negative correlation between BRG1 and TAZ expression (−0.803). There was a moderate negative correlation between ARID1A or BRM and TAZ expression (−0.422 and −0.518, respectively). No correlation was observed between PBRM1 or pAKT and TAZ expression (0.147 and 0.125, respectively). ( D ) Representative cases are shown. Scale bar, 20 μm.
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    Image Search Results


    Evaluation of SWI/SNF components and TAZ expression in human ITPN samples. ( A ) Expression of SWI/SNF components, including BRG1, BRM, ARID1A, and PBRM1, in human ITPN specimens. Additionally, the expression levels of pAKT and TAZ were analyzed. Black, blue, green, and red indicate negative, weak, moderate, and strong expression, respectively. Cases with reduced expression of any SWI/SNF complex component are shown in yellow . ( B ) Summary of BRG1 staining for human IPMN and ITPN samples. Immunohistochemistry for BRG1 in IPMN (n = 20), ITPN (n = 12), and adjacent normal pancreas (n = 3) specimens. Images of the adjacent normal pancreas were captured from the same tissue slide as IPMN or ITPN, if available. Scale bar, 20 mm. Tables on the right show the number of samples classified as ITPN or IPMN and their staining intensity. Statistical analysis was performed using the Mann–Whitney U test. ( C ) Analysis of Spearman’s correlation coefficients and scatterplots with jitter and linear regression. There was a significant negative correlation between BRG1 and TAZ expression (−0.803). There was a moderate negative correlation between ARID1A or BRM and TAZ expression (−0.422 and −0.518, respectively). No correlation was observed between PBRM1 or pAKT and TAZ expression (0.147 and 0.125, respectively). ( D ) Representative cases are shown. Scale bar, 20 μm.

    Journal: Cellular and Molecular Gastroenterology and Hepatology

    Article Title: Loss of Brg1 and Pten in Pancreatic Ductal Cells Forms Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

    doi: 10.1016/j.jcmgh.2025.101639

    Figure Lengend Snippet: Evaluation of SWI/SNF components and TAZ expression in human ITPN samples. ( A ) Expression of SWI/SNF components, including BRG1, BRM, ARID1A, and PBRM1, in human ITPN specimens. Additionally, the expression levels of pAKT and TAZ were analyzed. Black, blue, green, and red indicate negative, weak, moderate, and strong expression, respectively. Cases with reduced expression of any SWI/SNF complex component are shown in yellow . ( B ) Summary of BRG1 staining for human IPMN and ITPN samples. Immunohistochemistry for BRG1 in IPMN (n = 20), ITPN (n = 12), and adjacent normal pancreas (n = 3) specimens. Images of the adjacent normal pancreas were captured from the same tissue slide as IPMN or ITPN, if available. Scale bar, 20 mm. Tables on the right show the number of samples classified as ITPN or IPMN and their staining intensity. Statistical analysis was performed using the Mann–Whitney U test. ( C ) Analysis of Spearman’s correlation coefficients and scatterplots with jitter and linear regression. There was a significant negative correlation between BRG1 and TAZ expression (−0.803). There was a moderate negative correlation between ARID1A or BRM and TAZ expression (−0.422 and −0.518, respectively). No correlation was observed between PBRM1 or pAKT and TAZ expression (0.147 and 0.125, respectively). ( D ) Representative cases are shown. Scale bar, 20 μm.

    Article Snippet: PBRM1 , Bethyl , 1:500 , A301-591A.

    Techniques: Expressing, Staining, Immunohistochemistry, MANN-WHITNEY